The problems of managing the labor market and the employment of the population are given considerable attention   by   scientists,   economists,   philosophers,   and   sociologists.   Despite   the versatility of research, the problems of human resource management and improving organizational and economic management mechanisms remain insufficiently developed. Only at the regional level of  management  can  we  find  effective  ways  to  solve  the  most  acute  problems  of  building  high-quality  labor  potential  and  rational  use  of  labor  resources  by  developing  various  programs  and coordinating the activities of the relevant services. The  main  discrepancy  between  the  education  system  and  the  labor  market  comes  from  the lack  of  forecasting  methods  in  the  workforce  and  imperfections  of  the  mechanisms  of  social partnership.  This  is  due  to  the  insufficient  funding  of  educational  institutions  and  lack  of  job security for graduates. In addition, the low level of education of the economically active population of   the   region,   the   insufficiently   developed   training   system   for   innovative   industries,   the undeveloped  employment  system  for  graduates  contributing  to  the  imbalance  in  the  labor  market, i.e. with a general quantitative prevalence of labor supply over demand, the most important sectors of the economy were not provided with the required amount of qualified specialists. The  purpose  of  this  study  is  to  substantiate  the  theoretical  and  methodological  aspects  of human  resources  management  and  labor  potential,  to  develop  proposals  and  recommendations  for improving its organizational and economic mechanism.